Three young people on a road trip from Colorado to New Jersey talk to a trucker on their CB radio, then must escape when he turns out to be a psychotic killer.
On its way back to Earth, the space shuttle Nautilus passes through a cloud of alien spores causing its sole occupant, astronaut Steve Thomas to transform into a blood-thirsty monster. The shuttle crashes into a swampy region of central Florida, creating a situation which threatens contagion and/or death to all who encounter the shuttle or its mutated pilot.
When Jay and Silent Bob learn that their comic-book alter egos, Bluntman and Chronic, have been sold to Hollywood as part of a big-screen movie that leaves them out of any royalties, the pair travels to Tinseltown to sabotage the production.
Triton Indutries has created a genetically-engineered creature using DNA from human sources. During the course of the experiment, however, the host mother carrying the mutant escapes from the laboratory compound, giving birth shortly thereafter. The intellient "baby" beings hunting down and killing its male DNA donors, while at the same time trying to mate with its female donors. The head of the lab wants to destroy the monster before the press can get wind of the story, but the former head of security wants to expose the whole thing.
Following a childhood tragedy, Dewey Cox follows a long and winding road to music stardom. Dewey perseveres through changing musical styles, an addiction to nearly every drug known and bouts of uncontrollable rage.
A film archivist revisits the story of Rustin Parr, a hermit thought to have murdered seven children while under the possession of the Blair Witch.