Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.
Rachel Carson, a best-selling crime novelist, is devastated and filled with guilt over the accidental death of her son. Hoping that a change of scenery will help alleviate her suffering, she leaves her home in the city and moves into a vacant country house owned by a friend and begins a relationship with charming local Angus. But, just as her life is taking a turn for the better, Rachel realizes she's being romanced by a ghost, leading her to doubt her own sanity.
When Alfred Polly fails to find fulfilment as a shop keeper, he leaves his wife and sets out on the open road to see where freedom leads.
This time around, Chucky and his homicidal honey, Tiffany, are brought back to life by their orphan offspring, Glen. Then the horror goes Hollywood as Chucky unleashes his own brand of murderous mayhem!