In the seedy part of Los Angeles, a man who writes poetry has spent six months without leaving his apartment because of his paranoid delusions involving sadistic doctors, rappers, and spiders. A woman who seems to jinx things by wanting to help is dumped by her boyfriend and finds herself penniless on the streets, and soon runs afoul of a local gang. Due to a telephone glitch, the man calls her at a phone booth trying to dial a "talk line" and invites her to his place. There they must help each other to overcome their respective problems.
A pair of whacked-out cartoon-like exterminator/hitmen kill the owner of a burglar-alarm company, and stalk the partner who hired them, his wife, and a nerd framed for the murder, who tells the story in flashback from the electric chair.