A race of space vampires arrives in London and infects the populace, commencing an apocalyptic descent into chaos.
Victoria "V.I" Warshawski is a Chicago based private detective who agrees to babysit for her new boyfriend; then he is murdered. Being the detective type, she makes the murder her next case. In doing so she befriends the victim's daughter, Kat, and together they set out to crack the case.
Sherlock Holmes is brought back to life by Watson's female descendant after being cryogenically frozen for eighty years.
Mickey Almon is a sports star turned reporter covering the athletics in Moscow. Framed by the KGB and forced to confess that he was spying for America, he is sentenced to detention in a Gulag, a barbaric prison camp in the wilds of Siberia. Unable to prove his innocence, Mickey must either put up with the inhuman conditions or engineer an escape.
Sheena's parents are killed while on Safari. She is raised by the mystical witch woman of an African tribe. When her foster mother is framed for the murder of a political leader, Sheena and a newsman, Vic Casey, are forced to flee while pursued by the mercenaries hired by the real killer, who hopes to assume power. Sheena's ability to talk to the animals and knowledge of jungle lore give them a chance against the high tech weapons of the mercenaries.